My husband aged 45 years old, he is on secondline ART(Lopimune,Abamune,Tenvir EM)since June 2008.His initial illness started with oesophagitis and regurtation(difficult to take intake).Later he was diagnosed with Demyelinating problem (leftlower and upperlimb weakness) and then he had seizures thrice in three months period, during that time we taken MRI for him and doctors told he had HIV related leukoencephalopathy.Now he is on treatment to control seizures and for demyelinating problem.In between he had psychological disturbances.Still he had not recovered and i need your experts view on this.

PML (Progressive multifocal leukoencephalopathy) is a degenerative brain infection caused by the JC virus. There is no clearly effective therapy though some AIDS patients stabilize and recover if they receive effective HIV medication and have good immune recovery. Recovery is often better if milder case and a higher CD4 nadir level.

See http://aidsinfonet.org/fact_sheets/view/516

for more information.

KH