Mar 12, 2009
Hi Dr. Henry, I have a question and I would appreciate your opinion. I have been taking Atripla for the past 3 years and it has been working great as far as controlling my Hiv infection. My labs have been great my V.L has been undetectable for 3 years and my T- cells have increased. I do not have any resistance to any medication at this time, but find that Atripla has given me some Neurological issues. I have problems falling asleep, some if not most nights, and with that find it hard to concentrate on tasks during the day. I also find myself feeling foggy at times during the day.
My question is do you think its time for me to switch meds or should I tough it out. I am paranoid that if I switch meds I will be using up a line of medication before I need to switch. Atripla has been the only medication I have ever been on. My ID doctor has told me that I should switch if I am having these issues with Atripla. My ID doctor told me that a good alternative to Atripla would be Isentress plus Truvada. My doctor told me that Isentress is a good alternative and has a low toxicity profile. I was also thinking about Reyataz/Norvir + Truvada. I would appreciate any feed back from you and what you thought would be my best options.
| Response from Dr. Henry
There are many good choices to switch off an effective regimen in situations such as yours. I have had many patients switch to either of the two regimens you mention and they have done fine. If you want once a day the Reyataz regimen might get the nod while I concur that the raltegravir based regimen (currently twice a day dosing) has been very well tolerated. There is no head to head comparison between the two switching options-they are both good choices. KH
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