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Dec 12, 2008

What is the differnce between HIV1 and HIV2. Is efavinez effective against HIV2? Is the experimental drug TMC278 effective against HIV2?

Response from Dr. Henry

Efavirenz is not considered to be effective against HIV-2 due to specificity it has for binding in active pocket of HIV-1 (differenct than HIV-2 which is not a very common virus). Etrivirine and TMC-278 are newer NNRTIs thatn may have somea activity against HIV-2--I haven't seen much published from clinical studies on that question. If any reader knows of such a reference please post. KH

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