Dec 12, 2008
What is the differnce between HIV1 and HIV2. Is efavinez effective against HIV2? Is the experimental drug TMC278 effective against HIV2?
| Response from Dr. Henry
Efavirenz is not considered to be effective against HIV-2 due to specificity it has for binding in active pocket of HIV-1 (differenct than HIV-2 which is not a very common virus). Etrivirine and TMC-278 are newer NNRTIs thatn may have somea activity against HIV-2--I haven't seen much published from clinical studies on that question. If any reader knows of such a reference please post. KH
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