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Prophilaxis/drug resistance
Nov 16, 2008

hello good doctor.I would like to ask if a Prophilaxis such as Cotri for PCP would develop possible drug resistance if taken for long? i currently dont have access to my cd4/viral count so me and my doctor dont have a baseline when to stop.and what are the indications/sign or symptoms that Drug resistance has develop for ARV meds im taking? hope you can help me doctor. thanks.

Response from Dr. Henry

Fortunately cotrimoxazole (Bactrim or Septra or TMP/SMX) taken for prevention of Pneumocystis pneumonia rarely results in resistance. In the pre-HAART era many patients took cotrimoxazole for many years with continuing effectiveness. If at some point you get access to HIV drugs and labs testing then often the cotrimoxazole can be stopped once there is CD4 increase to > 200. KH

case basis

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