|HIV2 INFECTION AND TREATMENT
Jul 13, 2008
CAN I USE 3 NRTI DRUGS SUCH AS AZT/d4T/ddI,IN COMBINATION AS THE NNRTI DRUGS ARE INEFFECTIVE IN NORMAL DOSES, WHERE AS PI DRUGS WITH THE EXCEPTION OF NELFINAVIR,&SAQUINAVIR,THE OTHER PI DRUGS ARE RELATIVELY IN EFFECTIVE AND ALSO BECAUSE AND THE OPTIONS ARE LIMITED.
Response from Dr. Henry
There is fairly little data on the use of AZT/D4T /ddI together and my guess would be that the effectiveness would be modest/limited with a fairly high rate of side effects (AZT and D4T are both thymidine analogues and generally should not be used together). If you have NNRTI resistance then the next regimen is a challenge and generally should be a protease inhibitor based regimen preferably with ritonavir boosting (such as Kaletra or ritonavir boosted saquinavir) for best outcomes. That is a huge problem internationally as your questions indicates due to the limited availability of that option in many settings. KH
Likely side effects?
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.