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HIV2 INFECTION AND TREATMENT
Jul 13, 2008

CAN I USE 3 NRTI DRUGS SUCH AS AZT/d4T/ddI,IN COMBINATION AS THE NNRTI DRUGS ARE INEFFECTIVE IN NORMAL DOSES, WHERE AS PI DRUGS WITH THE EXCEPTION OF NELFINAVIR,&SAQUINAVIR,THE OTHER PI DRUGS ARE RELATIVELY IN EFFECTIVE AND ALSO BECAUSE AND THE OPTIONS ARE LIMITED.

Response from Dr. Henry

There is fairly little data on the use of AZT/D4T /ddI together and my guess would be that the effectiveness would be modest/limited with a fairly high rate of side effects (AZT and D4T are both thymidine analogues and generally should not be used together). If you have NNRTI resistance then the next regimen is a challenge and generally should be a protease inhibitor based regimen preferably with ritonavir boosting (such as Kaletra or ritonavir boosted saquinavir) for best outcomes. That is a huge problem internationally as your questions indicates due to the limited availability of that option in many settings. KH



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