Apr 6, 2008
By mistake I found that a 18 centimeter lymph nodes behind my neck is because of AZT.It came from no where and is breaking my neck. I'm taking Norvir, Invarase & Epzicom,which was changed combivir. What can be replaced to prevent futher discomfort?
| Response from Dr. Henry
AZT generally doesn't directly cause massive lymph node enlargement in areas such as behind the neck. If an enlargement/growth is found there it more often is a fat mass (buffalo hump). Such masses are a part of the lipodystrophy spectrum and have been reported in HIV+ persons on no therapy as well as among person on treatment. AZT has been linked mostly to fat loss-its link to fat gain is less clear and is complicated since other drugs, genetics, and a variety of HIV related non -drug factors (such as age, time with HIV infection, low CD4 counts) have been shown to contribute. If a person has a fat lump behind the neck while taking AZT the effect of switching to another drug is variable. Some patients (including a number of my patients) undergo surgical removal for cosmetic (and sometimes diagnostic) reasons. KH
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