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Managing Side Effects of HIV TreatmentManaging Side Effects of HIV Treatment
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Mar 14, 2008

What can you do to reverse lypodystrophy and wasting.

Thank you in advance

Response from Dr. Henry

Lipodystrophy involves gain or loss of fat. Fat gain is common in the general population as well as HIV+ persons on treatment. Exercise and diet can be helpful. Fat loss (lipoatrophy) is more unique to HIV infections and has been linked most closely with thymidine analogue drugs (D4T and AZT). Switching off offending drugs is important if that is an option. There are no interventional treatments for fat loss than can be universally effective or recommendeded. Various diabetes drugs, growth hormone or growth hormone releasing factor, uridine, and different injections/plastic surgery procedures have or are being evaluated for management. Wasting in the setting of HIV infection is most often related to poor control of HIV replication and/or intercurrent AIDS related infection. Poor nutrition, low androgen levels, and other factors can contribute to wasting. Effective control of HIV replication and provision of adequate nutrition (plus sometimes hormone replacement) are important interventions for AIDS related wasting. KH

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