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Managing Side Effects of HIV TreatmentManaging Side Effects of HIV Treatment
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nevirapine side effects
Feb 22, 2008

Hello from Germany, I am HIV positiv since may 2005(cd4 in that time 140 and VL 85000)Doctor said:start therapy! Ok,I choose nevirapine und truvada.I am now 4o years old male,fit und all this time I feel great.From 2006 bis 2008 CD4 400-550 and undectable VL.But,always since I jused my therapy, especially viramune caused high my liver enzyms and that up und down .Now 12.februar may leber enzyms are :ALT-100 and GGT- 230!AST, biluribin,kreatinin, good.In januar my ALT was 53.But GGT ist konstantly 200 1,5 years.I am very happy with my first line therapy and now i must changed something.I think i choose ATRIPLA.Ist that good options for me?The Bodycom ist my fevourite HIV forum and i ask a first time.I wish you alles gute aus Deutschland.Thanks, ALAN

Response from Dr. Henry

If your liver enzymes are elevated due to nevirapine then a switch to Atripla (substituting efavirenz for nevirapine) often would be beneficial. There are a range of issues that result in elevated GGT levels. GGT is sensitive to biliary tract disease. Can be sensitive marker for alcohol use and its effect on liver/biliary tract. Other drugs (like acetaminophen) can increase the GGT levels. Also sensitive to increases in liver/visceral fat--often with elevations in trigycleride levels as a part of the spectrum of metabolic syndrome or hepatic fat increase (hepatic steatosis). Elevations in GGT have not generally been pronounced for patients taking Atripla or nevirapine/Truvada. LH

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