If a regimen of HIV meds have similar side effects, symtoms like diarrhea or systemic like hypercholesterolemia,etc, can taking more than one mean these problems are more likely to happen and/or be more acute?

Generally many of the symptoms (some may be side effects from the drugs) seen in the setting of HIV treatment are helped if the regimen is potent enough to fully suppress HIV replication. Certainly there can be additive and overlapping drug toxicities. In areas of the world with a wide choice of HIV medications, there often can be switches made to find a regimen that is most suitable for a given patient for both side effects and viral control. Patients in our clinic are having less and less side effects from their HIV medications and less AIDS-related problems and symptoms than ever as the regimens have been continuously improving. KH