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epivir, kaletra, videx pediatric regimen
Dec 14, 2007

i have a pediatric patient who have been undetectable for over a year.now he is detectable at 1827 vl. he has home health twice a day. skill nurse gives him his morning dose of kaletra, videx and epivir at 0730 and his evening dose of kaletra and epivir at 1530. home health denies missing any dose, however, i feel that they may have missed and not reporting it. do you think that if this child is consistently receiving his medication everyday at the same time that he would be detectable since it is not spaced out the 12 hours between the am and pm dose. i say no because 1. kaletra is one of the most forgiving PI; 2. epivir can be given once or twice a day; and 3. videx is once a day. what do you think?

Response from Dr. Henry

I would check a genotype if possible to see if there is any evidence of resistance so far. All of those drugs can be given once daily so a switch to once daily observed dosing will help resolve the issue of whether doses are being missed. KH



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