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Elevated gamma gt liver enzymes
Dec 5, 2007

My ALT and AST levels are within normal range. However my gamma gt level is at 124 well over the acceptable level of 50. I am taking Sustiva, Abacavir and Tenofovir. Since I am not a "drinker" (at the most 3 glasses of red wine a month,) what could possibly account for this elevation, which I understand is usually associated with alcohol abuse?

Response from Dr. Henry

GGT levels can be increased from alcohol use, conditions causing biliary obstruction, fatty liver and many other liver/biliary tract conditions. Many drugs such as acetominophen and many anticonvulsants, hormones, and others can increase GGT levels. Hyperthyroidism is another condition that can result in increased GGT levels. Fatty liver (hepatic steatosis) is increasingly common in both the general population and HIV+ persons. Your current HIV regimen has not been linked to generally increased rates of fatty liver but there could be individuals who are more susceptible to that adverse effect though your regimen generally would compare favorably to many others that are widely used as far as liver safety issues. KH

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