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re: hgh and oxandrolone
Dec 1, 2007

HGH has proven to improve wasting but androgens have no benefit??

First of all, the studies that showed increased body mass due to hgh injections included BONE, CONNECTIVE TISSUE, and WATER WEIGHT as criteria for 'lean body mass'. therefore, the studies are clearly flawed and by no means show that hgh improves wasting syndrome (which is characterized specifically by loss of contractile muscle tissue). Serostim itself (the company) conducted the studies, so of course they did whatever they could to frame their product as an appropriate treatment for wasting. so they set up the rules. Besides this obvious bunk science they used in the studies, if you actually had any experience with patients taking Serostim, you would know that wasting patients generally have a bad experience solely using hgh as a remedy for wasting (particularly with the overdose serostim prescribes). and by the way, serostim prescribes such a high dose, because only an overdose results in so much water retention, bone growth, and connective tissue growth that a significant weight change takes place in the absence of fat gain. it's disgusting what serostim did with those studies.

anabolics and androgens actually do puff muscles up (although this has zero to do with countering true cachexia) so if we're talking about increasing lean body mass (and we're not manipulating the definition of lean body mass for the sake of legitimizing an illegitimate product) then anabolics and androgens certainly increase lean body mass (an honest definition of what lean body mass is - contractile muscle tissue)

but here's the bad news. even anabolics and androgens are NOT a proper treatment for true cachexia (muscle wasting). all these steroids do is puff your muscle cells up with nitrogen - they do not replace the cells you've already lost to your wasting syndrome. and once you stop taking the steroids and you deflate back to your normal cell capacity, you're left even skinnier than you were pre-cycle, because believe it or not, you were continuing to lose muscle cells while on cycle.

true muscle wasting/cachexia/sarcopenia - whatever you wish to call it - has nothing to do with malnutrition, mal-absorption, or lack of exercise. of course all these things will exacerbate the syndrome. but the strongest underlying cause of wasting syndrome is still not well understood. but it most likely has something to do with either the virus itself invading muscle cells and killing them similar to the invasion of cd4s, and/or the body's own overproduction of anti-inflammatory hormones and proteins that function to shrink the body's tissues down for the sake of curbing the effects of an infection or cancer.

the only drugs available that address the second mentioned probable cause of wasting are known as cytokine inhibitors. specifically tnf-a inhibitors. ask your doctor about this. the trouble is, your doctor probably knows as little about this as dr. conway. it's sad that these doctors are just sheep and have no real passion for these issues. if they did, they would never prescribe something like serostim to a patient in need of fighting hiv and wasting. by the way, serostim (hgh) has shown to raise viral load in patients not on haart. i would submit that even on haart, hgh is most likely increasing levels of hiv, cancer cells, or other harmful tissue in the body.

Response from Dr. Conway

Here at The Body, we honor the diversity of points of view that exist in the very complicated field of HIV/AIDS, which is why I have chosen to post this essay in an unedited form. What is best for a given individual in the treatment of any HIV-related condition (be it wasting or any other) is a matter for discussion between the person who will be getting the treatment and the one who will be giving it. In this context, it becomes crucial to have an oepn and frank discussion before proceeding.

This being said, the data on hgh have been generated in carefully designed controlled studies that have now been published in peer-reviewed journals. These studies (including more recent lower dose studies) confirm the benefit of hgh in wasting, so it remains a good option to consider, as long as the caregiver and the patient agree.



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