Sep 2, 2007
I am taking Viramune, Acyclovir and Epzicom and now i have high muscle enzyme that is causing so much pain. What to do?
Response from Dr. Henry
None of your current antiviral medications (for HIV nevirapine, abacavir, and lamivudine and for herpes acyclovir) commonly cause muscle damage (myopathy or myositis). In an occasional patient there may be a susceptibility to drug related muscle damage but more often there is another condition present. Exercise is a common cause of muscle pain and elevated muscle enzymes so it is important to get a blood sample after a period of several days without much exercise to see the baseline level of the muscle enzymes. A thorough history and physical examination are important to sort out the cause of your muscle complaints. Sometimes evaluation by a rheumatologist and even a muscle biopsy are needed to determine the proper diagnosis and treatment strategy. KH
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