Aug 13, 2007
Why are there rare cases of people who cannot ever seroconvert[produce antibodies to HIV infection]? I am talking about someone who has been healthy their whole life? I thought everyone produced antibodies to HIV if infected but I know now this is not always true but there must be a cause?
Response from Dr. Conway
If there is nothing wrong with your immune system, you should be able to produce HIV antibodies that will be picked up by conventional testing. The extremely rare cases when this does not happen (and you can almost count these cases on one hand), it is due to a very rare strain of the virus of a very different subtype. In those situations, there is almost always some other clue that infection is present (HIV antigens or plasma viral load, lowered CD4 count).
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