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options for sulfa allergy
Jun 19, 2007

Is is possible to simply get a list of PI's that do NOT contain sulfa components, so I know which ones are safe for me. I quickly develope Stevens/Johnson syndrome from drugs like Sustiva, and Bactrim. Please help.

Response from Dr. Henry

Particular caution is warranted if trying to use tipranavir, darunavir, or fosamprenavir in patients with a sulfa allergy. I have mostly used Kaletra (there is a sulfa in ritonavir but in my experience doesn't seem to be as prone to sulfa cross reactions), and to a lesser degree saquinavir, and nelfinavir in sulfa allergic patients with generally good results (common sense/careful monitoring still advised). I don't have much experience with indinavir (contains a sulfa moiety as well) so can't comment further on that as an option. YOur question is a very good one so reader comments or any references to published articles on the subject are welcome to be posted. KH



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