|Effect of efavirenz on lansoprazole
Mar 3, 2007
I've been on HAART (Kivexa and efavirenz) since September 4th and had an excellent response, currently VL<40 and CD4 671 31%, from VL 120,000 and CD4 420 21% at baseline. For the past 3 years I've been treated for oesophageal reflux with omeprazole 20mg daily. In December this was increased to 40mg as symptoms were returning and this worked fine. A couple of weeks ago my GP (family doctor) changed by ppi to Lansoprazole 30 mg, which doesn't seem to be working as well. I understand from 'net research that efavirenz can reduce the efficacy of lansoprazole. Is this by a considerable degree (which may explain my returning symptoms) and does efavirenz also effect the efficacy of other ppi's? Thanks for your help and this great site. Steve in UK
| Response from Dr. Henry
Generally proton pump inhibitors are OK to take with efavirenz based regimens. If there is a concern an efavirenz blood level could be checked. KH
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