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Factor 4 Lieden Mutation
Apr 9, 2001

A year ago I was diagnosed with a pulmonary embolism and spent a week in the hospital on heprin. The doctors found several blood clots in my lower right leg which they had no explaination. A test was done and it was determined that I had a genetic disorder known as 'factor four Lieden mutation' (I may be wrong on the spelling). I am 42 years old and I was wondering why this hasn't come to light before now. I have no family history of this type of disorder. Prior to this I was taking Zerit, Epivir, Crixivan and Videx as my HIV treatment. My blood tests were consistantly good. Has anyone else reported 'developing' a genetic disorder while on HART? I have since changed my HIV medications, but would like to discontinue the Warfarin at some point. Thank you for your help.

Response from Dr. Boyle

Antiretrovirals would not have caused the gentic problem you have. There have been no reports of genetic mutations such as this occurring in the adult population.



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