|Restart Meds after Lactic Acidosis
Jan 19, 2007
I spent nearly 20 years on mostly NNRTIs and my T-cell counts were well maintained. I started a lactic acidosis event. I stopped all meds ( most recently just Combivir). I have regained most of my strength, but my viral load and T-cell count deemed that after 8 months of no retrovirals I needed to start a new regime. My Dr. has added NNRTIs to this regime, is this wise? What are the alternatives to using this class of drugs?
| Response from Dr. Henry
Lactic acidosis is most often seen in regimens containing the thymidine nucleoside reverse transcriptase inhibitors (NRTIs not NNRTIs) particularly D4T > AZT. After lactic acidosis oftren NRTIs can be used as a part of an effective regimen but the D4T or AZT is usually replaced by abacavir or tenofovir. I have also avoided NRTIs altogether in some patients using a double boosted PI regimen with reasonable effectiveness. KH
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