|response to gastro-intestinal "cure"
Jan 15, 2007
Very interesting. As a biochemist specialised in the microbial interactions "microbial ecology", quite a lot is being studied concerning gas formation in the gut, the role that certain types of bacteria play in the GI-tract, what distrubances lead to, .... The use of pre/probiotics (probiotics: bacteria that have a beneficial effect on the composition of the GI bacterial flora, prebiotics: chemical compounds such as inuline that favor the growth of probiotic bacteria) can certainly help there, as is proven by several studies. As far as i know (i don't read medical articles that often) there have been no/few studies to determine the effect of HAART on the GI flora. It might be considered for further research, that side effects need not necessarily be interactions between patient/meds, but also between GI flora and meds. As quite a few meds are degraded by bacterial cytochromes and cometabolic processes, this is not far-fetched at all. I'm not on HAART now (CD4 at 560/26%, VL 4,4K) but my partner is on PEP since a condom rupture a week ago. I've been giving him a pre/probiotic commercially available mixture of lactic acid/bacillus thermophilus/... m.o.'s and so far the combivir + nelfinavir (notoriously known for GI trouble) have shown... no side effects at all. Dr's, if interested, let me know, i'd be happy to exchange thoughts on this.
| Response from Dr. Henry
Your thoughts on the topic of HIV therapy and the gut/gut flora are interesting and appreciated.
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