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Best Combo Options for New Regiments
Dec 6, 2006

With all the positive news of one-a-day combo meds and new research studies pointing out the benefits of a particular combination of meds being more favorable than another, I would like to know what kind of drug combination options are best for patients beginning new treatment and what other variables or options should be considered before starting a regiment for the first time given the recent studies??

Response from Dr. Henry

There are many good choices available for initial treatment in the US and no one choice is the clear favorite. A good example of choices under evaluation is ACTG 5202 which is comparing starting either a NNRTI based regimen (efavirenz) or boosted PI regimen (ritonavir/atazanavir) + either one of two dual NRTI combinations that are once a day and thymidine analogue sparing (either Truvada or Epzicom). Individual issues important to factor in include renal status, interest in child bearing (for women), liver status (hepatitis B/C), cardiac risk, and many others. HIV specialists are used to discussing these issues with patients. KH



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