Oct 29, 2006
I have been suffering from a frozen shoulder for about 10 months now. Have seen a several chiropractors, osteopaths, done x-rays (have a bit of arthritis but not enough to limit my movement). Much pain in my shoulder and mobility to about a third of what I had. I'm HIV positive since 25 years now. Living in France, so have had some of the best care available. All the meds, Anti protéases since 1995. Heavy duty cocktail. Just saw a rheumatologist who has made a connection to long term HIV meds (especially anti proteases) and blocked shoulders. There is a service in his hospital with an acknowledgeable number of HIV patients who have the same problem. This is the first time I have heard of the meds affecting the shoulder. I did read some of your responses to previous shoulder pain questions and found you rarely make this connection. Your thoughts on this matter would be appreciated. Marc
Response from Dr. Henry
I am unaware of any study linking use of protease inhibitors with joint abnormalities or frozen shoulder to be specific. I have hundreds of patients on protease inhibitors-some of whom have shoulder problems. In most cases the shoulder problems has been related to tedonitis, capsulitis, or osteoarthritis. I have not had the impresssion from either my experience or comments from the rheumatology consultants that protease inhibitors are in some way causing the problem. I would be interested in hearing from any reader if they are aware of any studies noting such a linkage. There are a variety of joint problems that have been reported in HIV+ persons but the linkage to protease inhibitors has not been established to my knowledge. KH
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