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Stress & CD4
Oct 25, 2006

How does stress in an Hiv person affect their CD4 count?

Response from Dr. Henry

That is a good question that is difficult for me to answer with much confidence. There are a few published studies noting that high stress levels many negatively impact immune function/CD4 status in the setting of HIV infection but they are not entirely convincing to me. There are some many factors that can impact CD4 count (including genetic factors and degree of immune activation as well as degree of HIV control, thymic function and more)that the role of stress per se can be tough to isolate. Most patients do well on effective HIV therapy across a wide range of stress levels. Untreated stress or depression can negatively impact adherence to medication which can result in less of a CD4 recovery. KH



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