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Type 2 diabeties
Sep 13, 2006

Several of my friends included one guy who has been HIV for 25 years have suddenly been diagnoised with type 2 diabeties, is this somehow related to the HIV medications, my doctor doesn't want to admit this?

Response from Dr. Henry

Good question. The incidence of diabetes is increasing in the general population so it can be difficult to sort out the contribution of HIV or anti-HIV medications. The increasing rates of obesity in the US contributes to the overall increase in the general population. Risk for diabetes increases with age and also can have a genetic component so that persons with close relatives with diabetes are at increased risk. Effective HIV treatment can reverse weight loss due to HIV/AIDS but could then contribute to risk for diabetes as a patients survives their HIV for a long time. Certain HIV medications may trigger more metabolic/lipid/glucose abnormalities than other medications with some of the susceptibility to HIV drug effect perhaps being genetic ( a small % of patients may be highly susceptible when many/most are not). HIV specialists can usually sort out if a given regimen is significantly contributing to new onset diabetes and what switch options are available. KH

Protease enzyme inhibitors
mitochondrial dna testing for lipodystrophy/atrophy

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