|autoimmune disease and HIV test
Jul 16, 2006
Dr Conway: I have Uveitis and use Prednisolone eye drops for last 5 years on and off. I have done 7 ELISA HIV 1/2 tests since my last exposure 7 mo ago. Since Prednisolone can impact antibody production and a false negative result can happen, I have also done a DNA PCR test at 5 mo and the result was negative. Now I learned that DNA PCR does not detect some subtypes and also HIV-2. Should I do a RNA PCR(amplicor 1.5) which claims to detect all subtypes? I am not sure what version of Amplicor they used for my PCR test. I have enlarged tonsils (no infection) and chronic fatigue for last six months now. I have seen an ENT specialist and he thinks my tonsils are big but symmetrical. Can it be PGL? I also have a constant discomfort on my left tonsil. I do not see any other swollen node and no other hiv symptoms, but my fatigue is taking a toll on my day to day life. Thank you very much for you time.
| Response from Dr. Conway
Prednisolone eyedrops do not produce systemic immune suppression, and would not affect the results of your HIV test. As for HIV-2, it would be effectively ruled out by the antibody test that was done, so I would not worry about this infection being missed. RNA PCR testing at this stage does not appear to be necessary for you, as I think that infection has been effectively ruled out. I might do a CD4 count if I thought your chronic fatigue were significant, but that would be it. What you describe as symptoms is not at all consistent with PGL, so I wouldn't worry about this either...
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