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Managing Side Effects of HIV TreatmentManaging Side Effects of HIV Treatment
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autoimmune disease and HIV test
Jul 16, 2006

Dr Conway: I have Uveitis and use Prednisolone eye drops for last 5 years on and off. I have done 7 ELISA HIV 1/2 tests since my last exposure 7 mo ago. Since Prednisolone can impact antibody production and a false negative result can happen, I have also done a DNA PCR test at 5 mo and the result was negative. Now I learned that DNA PCR does not detect some subtypes and also HIV-2. Should I do a RNA PCR(amplicor 1.5) which claims to detect all subtypes? I am not sure what version of Amplicor they used for my PCR test. I have enlarged tonsils (no infection) and chronic fatigue for last six months now. I have seen an ENT specialist and he thinks my tonsils are big but symmetrical. Can it be PGL? I also have a constant discomfort on my left tonsil. I do not see any other swollen node and no other hiv symptoms, but my fatigue is taking a toll on my day to day life. Thank you very much for you time.

Response from Dr. Conway

Prednisolone eyedrops do not produce systemic immune suppression, and would not affect the results of your HIV test. As for HIV-2, it would be effectively ruled out by the antibody test that was done, so I would not worry about this infection being missed. RNA PCR testing at this stage does not appear to be necessary for you, as I think that infection has been effectively ruled out. I might do a CD4 count if I thought your chronic fatigue were significant, but that would be it. What you describe as symptoms is not at all consistent with PGL, so I wouldn't worry about this either...

endorsing viral load tests?
PEP effectiveness once a fever is produced

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