change from P.I. to NNRTI
Jun 26, 2006
I changed from P.I.contained regiment to NNTRI combo 8 years ago and been working well until recently now my V.L. is 150 (used to be <50).My doctor adopted wait and see strategy. Is it really true that P.I. regiment will work for me as I never developed resistance to P.I. Many thanks
Response from Dr. Henry
A one time viral load or intermittent viral load elevation from undetectable to 150 copies/ml is called a blip and often will resolve with the viral load returning to undetectable without any intervention other than making sure no doses of medications are missed. If you have developed mutations associated with resistance to NNRTIs then often switching to a boosted protease inhibitor will result in viral suppression particulary in cases when there is little to no history of protease inhibitor resistance. KH
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