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Managing Side Effects of HIV TreatmentManaging Side Effects of HIV Treatment
           
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IRIS Information
May 12, 2006

A few months ago I began HIV meds (CD4:4), (Viral Load:>100,000). I developed IRIS in my intestine/colon within 45 days and was hospitalized. Just now trying to get off of prednisone and get my CD4 count up. Question: I have read that once you have IRIS your CD4 count rises much much slower than if you had never had IRIS. Is this correct? And, there are positive aspects of having had IRIS?

Response from Dr. Henry

I haven't seen convincing data that experiencing an IRIS reaction has a predictably negative effect on CD4 recovery. That hasn't been my own experience with patients in our clinic who develop IRIS-their CD4 recovery varies but seems similar to other patients. Use of corticosteroids however can decrease CD4 counts depending on the dose and patient so that is a complicating factor. KH



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