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Interleukin-2 hiv treatment dosag
Feb 17, 2006

what is best dosage

Response from Dr. Henry

Interleukin-2 has not been approved for the treatment of HIV infection since there has been no study that has clearly demonstrated a significant clinical benefit (prevention of death or AIDS related problems). Il-2 is relatively expensive and has numerous sometimes serious toxicities. Several large clinical studies (such as SILCAAT and ESPRIT) are evaluating whether the increase in CD4 cells seen with IL-2 results in a clinical benefit. Typical dosing for IL-2 is 4.5 million units subcutaneously for 5 days repeated every 8 weeks or so until a target CD4 count is reached and then used intermittently depending on the CD4 count. Doses are increased or decreased in response to individual toxicities and CD4 responses. KH



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