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combivir and nevirapine in relation to low sperm count and erection problems.
Feb 11, 2006

My husband has been on combivir and nevirapine for the past four years. We have found out we can't conceive because his sperm count is low but also has erection problem. Could this have been caused by his treatment and if so would it help switching to another combination therapy and which one d you recommend please?

Response from Dr. Henry

Good question. Low testosterone levels are common in HIV+ men and can contribute to low sperm counts (not usually related to the HIV regimen). I am not aware of strong data showing improvements in sperm counts when switching HIV regimens. It is possible that mitochondrial toxicity from the AZT in the Combivir could cause a low sperm count in a small subset of men. Switching off a thymidine analogue to something like abacavir or tenofovir might help in that situation. KH

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