Oct 4, 2005
Hi... Totally successful one year treatment on sustiva/truvada; cd4 729, VL undetectable, 27%. Never had an OI. I have plenty of energy & feel totally normal except for one thing; Almost every day, usually around 3-4 pm, sometimes later, I get a sort of generalized malaise or achey feeling as though I were about to come down with something. It feels as though I had a low grade fever, but my temp. is normal. It resolves when i take an advil, but troublesome nonetheless. Do you have other patients in my situation with this complaint? Is it some sort of low-level drug toxicity. I hate to stress my liver/kidneys taking advil every day...
Response from Dr. Henry
Fatigue/malaise is fairly common in the general population and may be more common in HIV+ patients even when doing "well" blood test wise on treatment. Sustiva can have persistent subtle side effects. Assuming your renal function and other safety labs are OK (monitored when taking tenfovir) then unlikely to be due to a organ toxicity from your drug regimen. Often stress and sleep abnormalities (often aggravated by Sustiva) can cause some symptoms like you describe. KH
Treatment stopped temporarily
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