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Managing Side Effects of HIV TreatmentManaging Side Effects of HIV Treatment
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Treatment stopped temporarily
Oct 4, 2005

I recently started sustiva/truvada treatment,first of any treatment, after 8 days broke out in rash from neck to toe. Additionally, i was on bactrim, but the doc stopped that temporarily. I havent had any complications VL 28,000 CD4 220. Doc is out of town, and Nurse practictioner told me to stop taking all medicines and take benadryl to calm the rash. Is this a good idea? Ive only been taken the treatment for 11 days...will the HIV become resistant?

Response from Dr. Henry

I am often uncomfortalbe stopping a Sustiva based (also with 3TC or FTC) regimen in the setting of active HIV replication due to concerns about resistance. I often treat through the rash with Tylenol/benadryl/fluids and careful observation with a regimen like yours (more cautious if taking abacavir or nevirapine when the rash can be a clue to a very serious hypersensivity reaction). I would be more persistent regarding either continuing the regimen with symptom side effect management and very careful clinical follow-up or switching to a boosted protease inhibitor based regimen. KH

Muscle gain
General malaise

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