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Help GW873140 seems to have failed
Sep 20, 2005

It seems the "side effect free" CCR5 inhibitor GW873140 trials have been stopped due to toxicity. So many of us were banking on success to revolutionise the treatment of HIV. What do you think the outcome of this failure may be?

Response from Dr. Henry

The Pfizer R5 inhibitor is still actively being evaluated as are other drugs with new targets (including maturation and integrase inhibitors). TMC114 from Tibotec looks promising against protease inhibitor resistant virus and Reverset looks good against nuke resistant virus. There are also a number of non-nuke reverse transcriptase inhibitors against against standard non-nuke resistance virus so the new drug development process is still quite active (though never fast enought). KH



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