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Managing Side Effects of HIV TreatmentManaging Side Effects of HIV Treatment
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Non-Sustiva sleep problem
Jun 2, 2005

I have been positive since 1985. My CD4 is at 29 (up from 19), viral load 101. I was off of HIV meds for about 3 years due to side effects for which I have shown a propensity. ie Zerit-neuropathy, Sustiva-serious suicidal ideation, Norvir-pancreatitis, etc. I am currently taking Truvada, Reyataz, and Norvir (low dose) and my viral load dropped from 55,000 to 101 in one month. I have always slept between 9-10 hours a night for more than 10 years which has been restorative I believe. Since starting my new regimen, I cannot sleep more than 8 hours and I get tired a lot faster and easier. I also have been taking (for many years) Klonopin 2 mg cumulative throughout the day, and 100 mg of Doxepin. Probably the worst part is waking up with my mind going a mile a minute. Is this common with any of these HIV drugs? This change took place almost immediately after beginning this group of meds.

Thank you for your help.

Response from Dr. Henry

Norvir may increase the levels of both Klonopin and the Doxepin so your sleep problems may be related to thatinteraction. You should discuss with your HIV specialist and/or pharmacist/psychiatrist. KH

side effects of ARV Drugs
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