PEP and rashes
Apr 27, 2005
I recently ( 10 days ago) started PEP therapy ( Combivir and Sustiva) after a potential exposure. The first couple of days were a bit spaced but after that I just felt nauseous a couple of hours after the Combivir. My problems are in the last couple of days. I have been waking up half way through the night and unable to get back to sleep ( I take 600mg Sustiva at night). Worse still, yesterday I awoke with a rash which covers my whole body apart from my face and hands. It was incredibly itchy at the start but after one Clarityn yesterday morning it has become non-itchy. My temperature is 36.5 and I feel fine apart from this rash. Could I be sero-converting even though I am on PEP, or is this rash common with the drug combo that I am taking. I am absolutely freaking out because my exposure would be ranked as low to medium risk. My specialist was even reluctant to prescribe but decided to err on the side of caution. I have since started to travel and cannot contact him to ask his opinion on this rash. I am alone in a foreign country with no support and fine myself scared and confused.....
I hope you can help.
Response from Dr. Henry
Rash likely due to Sustiva. Chances for serious adverse reaction to your meds seem to outweight chance for seroconversion. If you are seroconverting (unlikely) then the drugs didn't work and I would be concerned about drug resistance developing. A compromise would be to just continue the Combivir. KH
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