Neuropathy in legs and 3TC?
Apr 11, 2005
I've been positive for probably over 20 years and on meds for 8 years. Currently on atazanavir, abacavir and 3TC once a day, undetectable (for 7+ years) and CD count around 6-700. Had neuropathy when diagnosed in 1996 from HIV which declined on meds, though have continued to have mild and fluctuating numbness/aches at times. Recently (last few weeks)have had more pain and aches in feet and calves and even thighs/buttocks after sitting still for a period of time. Now more painful than before (more on left side than right, though present in both).
I'm wondering whether my change to once daily dosing, particularly of 3TC around 6 months ago, could have caused the worsening neuropathy (if that is what it is). Can the higher once daily dose of 300mg be more likely to cause neuropathy than the twice dailing 150mg?
Response from Dr. Conway
It is highly unlikely that the once daily dose of lamivudine makes any difference in the side effect profile of this drug, which is quite benign to begin with. Over the past 12 years, I have only ever encountered a single case of neuropathy that could be convincingly attributed to lamivudine.
Before deciding you had neuropathy, though, I would want to make sure there isn't something else going on, such as a rheumatologic disease of some sort, or a myopathy (either due to your NRTIs or for some other reason). If neither of these apply, I would be sending you to see a neuroplogist for nerve conduction studies to confirm that a peripheral neuropathy is present before making this diagnosis.
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