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fibrates and statins
Jan 23, 2005

Some Cardiologists in Rio are prescribing fibrates and atorvastatin ,together,as lipid lowering agents and for prevention of CAD.Is this combination a safe approach in patients on Kaletra or Crixivan? What would you suggest? Thanks Carlos Michalski M.D.

Response from Dr. Conway

The fibrates are often used to control the triglycerides and the statins to control the cholesterol. Depending on the problem, we have often used both together. Although it is safe to use them with either Crixivan or Kaletra, an alternative strategy to consider is single drug switching. If the viral load is undetectable, you can jsut replace the Crixivan or Kaletra in the HAART regimen with another drug that is not associated with lipid abnormalities. This can often simplify the overall regimen and rduce rather than increase the number of pills a patient is taking.

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