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Managing Side Effects of HIV TreatmentManaging Side Effects of HIV Treatment
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Lipodystrophy then switching treatment
Dec 10, 2004

I have been on kaletra,zerit and 3tc for 8months,has developed lipodystrophy with high cholestorol. Doctor suggested that i take a break for 3-4 months then start on new drugs. He has suggested 3tc, videx and viramune. Do you think this is a good combination? if not, which one would you suggest? How is Reyataz and trizivir? Iam looking at something that could reverse lipodystrophy. Thank you

Response from Dr. Henry

If you have been sick with AIDS or have had a CD4 count < 200-250 mI generally don't advise stopping HIV therapy in moist cases. Switching from D4T to abacavir fopr instance might slow down and slowly reverse the fat loss. Nothing has been proven to routinely and dramatically reverse fat loss over the short term. The other regimens you mention might well be more fat friendly. Their advisability depends on any history of drug resistance and other individual considerations. Switching over to a new regimen in the setting of full viral suppression is often successful and maintaining viral control. KH

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