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Managing Side Effects of HIV TreatmentManaging Side Effects of HIV Treatment
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Triglycerides high
Oct 28, 2004

Dr. Henry, As an update, I am writing now to get your ideas on some recent developments. Previously, my last CD4 was 343, VL=150, and triglycerides 601. Switching from Kaletra & Viread to Lexiva/Norvir/Viread my CD4 dropped to 212, but VL is now <70. The triglycerides have gone up to 790, and my gastro doc said it's time for Lipitor, 20mg. I was taking Omega 8 Fish oil to lower my cholestrol, but it shot up to 2001 my tri's were 179...I have not changed my diet other than increasing the fiber content eating Smart Start cereal (25g) of fiber, and now taking metamucil as I was having loose stools with Kaletra and Lexiva...I take some Immodium to bring form to my stools, and have plenty of calcium in my diet according to my doctor. Any ideas what would be causing this decline in CD4 and increase in triglycerides? As always, your input is very much appreciated. JJ

Response from Dr. Henry

I assume you have been evaluated by a good nutritionist and exerecise some? When ritonavir is used with Lexiva the amount is the same as you get in the standard Kaletra dosing so that might have gained much for you. Ritonavir + atazanavir may be easier on the lipids but may not be the best option if you have some background PI and/or nuke resistance. If your LDL fraction isn't too bad then the problem may be more the triglycerides which may respond to fenofibrate. If you have a pre-diabetic state (metabolic syndrome) then use of one of the diabetic drugs might help some. Making sure your thyroid and testosterone levels are OK can be useful too. Just a few ideas. Nevirapine is likely the most lipid friendly NNRTI so whether that class of drugs may be an important part of your HIV regimen could be reviewed by your HIV doc. KH

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