cutting edge therapies for wasting?
Sep 9, 2004
Have you heard of hydrazine sulfate or thalidomide? Are these therapies any good for wasting? Have you ever prescribed either one, and if so, what were the results?
Response from Dr. Conway
Thalidomide has a checkered past, causing congenital abnormalities almost a half century ago. It is still used as an anti-nauseas drug, and also to treat leprosy. It was initially thought to have anti-HIV activity, but this never really panned out. It is sometimes used to treat refractory oral ulcers in HIV-infected patients. I am not aware of its use or efficacy for wasting.
Hydrazine sulfate has been used for over 25 years in various settings to treat cancer-associated wasting, with some good results being reported (although not always). It was to be evaluated for HIV wasting, but I am not aware of any results that have been reported.
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