Liver Function and Viramune/Testosterone
May 20, 2004
I have a question about long term liver toxicity.
Would you suggest anything to minimize this?
Response from Dr. Henry
If you have been on that HIV regimen for a while then the rate of new liver toxicity seems low. There is not much data on the liver safety of very long term use of depo-testosterone. There is no confirmed way to prevent liver toxicity with any form of alternative therapy (i.e. milk thistle) though there is interest and many anecdotal reports. I continue to monitor patients liver status every 3 months or so in my patients on a regimen such as yours. Pushing good hydration and nutrition and avoiding other liver toxins (such as excessive alcohol or Tylenol) is also important. Protecting against hepatitis A/B with vaccination is another way to try and avoid liver problems. KH
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