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Stopped drugs due to high lactic acid levels while I'm on Chemotherapy
Apr 13, 2004

My doctor has stopped all of my HIV drugs (Crixivan, Norvir, Videx, Combivir) as blood test shows high lactic acid. I am on chemotherapy (CHOP) for Lymphoma. I am half way through the chemotherapy regimen. Our concern is with starting new drugs at this point as the chem would impact their effectiveness. What strategy do you recommend? Thanks. Gary

Response from Dr. Henry

That would depend on many factors including your past HIV history, presence of resistance, bone marrow status, etc. I often use a bone marrow and mitochondrial friendly regimen if possible in similar circumstances (avoiding possibly all NRTIs including AZT and D4T with 3TC/FTC/abacavir being still a possibility as well as the NNRTIs and PIs). Generally I try to get the HIV under control in the setting of lymphoma if a reasonably well tolerated regimen can be constructed. KH

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