I started taking meds 110 days ago. I am on viramune, viread, epivir twice a day. I have missed 4 evening doses and 2 morning doses in the past 100 days. Sometimes I take my morning dose a few hours late but never outside of the 3 hour window i've been told about. If I really clamp down now should I be OK or should I throw in the towell and switch to a once a day treatment. I would like to try to find some new ways to remind myself to take my meds before I change. On the other hand I'm wondering if its worth the risk. How long does it take to build resistance? At what point, if I still haven't manage to achieve the 95 mark, should I ask to be changed to a once a day which I assume would be a change from viramune to Sustiva. I wanted to avoid Sustiva because of the cns side effects but I take my chances with nightmares if it means not building resistance.

It has been said that the US average for adherence is 70% (many would quibble with that) so you are doing very good from your description. Missing 6 out of 220 doses is an overall A in the adherence world so you can continue trying to work with your current regimen if you otherwise are tolerating it well. Resistance is unlikely in the absence of prior resistance when the adherence level is near 97%. The CNS effects of Sustiva usually subside over the first month so a once a day regimen trying Sustiva is a consideration if that approach to dosing is important to you. KH