|Timing of medication is off
Jan 27, 2004
Hi,i started taking medication 5/03 cd4 324 and vl240000 and was undetectable 9/03 and cd4-650.ive been undetectable sense than.. I started with trizivir viread and viramune but the doctor took away the viread and the last 3 lab tests he only took the viral load and that was a total of about 3 1/2 months.do you think the cd4 changes much?I exercise alot and eat relatively good,but getting to the original ? i have over sleep a few times and have been off by 20-40 minutes and than take it 20-40 mins later in the evening but its always been 12 hrs apart.Do you think if the timing is off by that much i will create a resistance? And is that a good cocktail in your opinion for long term use? Will it create liver or heart problems? Thank you very much for all the advise its very helpful.
| Response from Dr. Henry
Ocasional doses of Trizivir taken a few hours early or late rarely result in the development of resistance (as opposed to missing doses entirely). The nevirapine, 3TC and abacavir all have fairly long half-lives within cells so that there is a cushion for some variation in timing. I doubt that you will have a problem with the situation you outline. I think that your doc is on target continuing Trizivir + one other drug to maximize long-term control of your HIV infection. KH
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