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A good combination?
Jan 8, 2004

Is Viread plus ddI plus Sustiva a good combination? I'm sensative to these three but resistant to AZT and 3TC. I take Viread, Sustiva, and Kaletra now with VL less than 50, but I am growing wary of the high triglycerides, colesterol and now possible glucose intolerance. I was wondering if it would be wise for the substitution of ddI for Kaletra. Thanks. Terry

Response from Dr. Henry

With some NRTI resistance I would be concerned about changing the Kaletra (high barrier to resistance) to ddI. If available another option might be low dose ritonavir + either atazanavir or phosamprenavir (those may be more lipid friendly then Kaletra). You might also consider non-boosted atazanavir or phosamprenavir but the dosing with Sustiva might be a bit tricky and variable. KH

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