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a non nrti combo
Dec 28, 2003

is ther a combo out there that does not include any nrti's and has shown successful in limiting lipodystrophy?

Response from Dr. Boyle

Some studies have produced some preliminary evidence that regimens that include 2 protease inhibitors, with no nucleoside ananlogs, may decrease the risk of lipodystrophy. Other studies have not found this to be true, and the long-term efficacy and safety of these regimens has not been fully established. There is also some evidence that thymidine-sparing regimens that include a non-nucleoside reverse transcriptase inhibitor and 2 non-thymidine nucleoside analogs (i.e., not AZT or d4T) may also limit the risk of lipodystrophy.



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