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Managing Side Effects of HIV TreatmentManaging Side Effects of HIV Treatment
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Therapy without a Protease Inhibitor
Dec 21, 2003

Viracept was causing erratic diarrhea. My doctor switched me to Kaletra. My combo is currently Kaletra, Videx, Viramune, and Viread.

The side effects of the Kaletra are worse than those of the Viracept.

Can a combo therapy work without a protease inhibitor?

Response from Dr. Henry

Yes many effective regimens are available that don't contain a protease inhibitor. Whether any of those are an option depends heavily on whether you have failed any previous regimens or have a resistance virus. Use of nevirapine(you are already on that) or efavirenz is a common way to avoid protease inhibitors. Several of the recently approved (in the US) PIs may be better tolerated than Kaletra (such as Reyataz or phosamprenavir) is another option. If your HIV doc recommends staying with the Kaletra, use of calcium supplements, fiber tablets, or immodium can help the loose stools for some patients. I assume you don't have any active other GI problems/GI parasites? KH

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