Dec 7, 2003
I am on 4mg of Avandia to help facial lipoatrophy . I have been on it for about 9 months now and have not seen any improvement, maybe in fact a slight worsening (though that could be the meds or ?) The meds I am on are the friendlier ones (abc, viread, viramune). My question is could the avandia be making the lipo worse? Is it worth staying on the avandia for at least a full year or just stop now since I am seeing no difference? I know it may take a year or more for some fat to recover. Thank you for your time.
| Response from Dr. Conway
Three studies have reported the effects of therapy with rosiglitazone (Avandia). Jarvinen and colleagues from Helsinki performed a placebo-controlled trial using 8 mg of rosiglitazone for 6 months, and was unable to show a statistically significant difference in either visceral or subcutaneous fat. Gelato and colleagues from Stony Brook Hospital in New York performed an open-label study in 8 subjects, and demonstrated a 23% increase in mean sub-cutaneous fat. Hadigan presented the results of a randomized, placebo-controlled trial of rosiglitazone at the recent 5th Workshop on Lipodystrophy. Therapy was placebo-controlled for 3 months, and then followed by 3 months of open-label therapy (so total therapy for 6 months). A 5% increase in leg fat was noted at 3 months, and a 12% increase in abdominal fat at 6 months. I am not aware of any information suggesting a worsening of fat loss with Avandia. My colleague Dr. Moyle suggests there may be more data at the Retrovirus meeting in February 2004. If I were you, I might wait until then to review the information and make up your mind, paying attention to the dose and duration of Avandia therapy that will have been shown to work.
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