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IL-2 & liver function
Dec 4, 2003

I have recently completed my first cycle of IL-2. When my labs came back from day 4 several of my results went from normal to 'out of range'. Specifically Alkaline Phosphatase, AST (SGOT), ALT (SGPT). The value that really bothers me is the liver test called GGT which went from 14 to 417. Is this a sign that my liver cannot tolerate the IL-2 treatments? What exactly do these tests measure?

Any light you could shed on this would be greatly appreciated. Thanks.

Response from Dr. Henry

Interleukin-2 often results in intrahepatic cholestasis which would result in elevations in liver enzymes (20-40% rates in 2 trials when IL-2 used for treatment of renal cancer). Those enzyme elevations almost always reverse within 5-7 days. Life threatening liver problem have occurred in < 1 % of patients in clinical trials. KH

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