Nov 5, 2003
I have been on Sustiva and Trizivir for a year. This is the first cocktail I have been on.
Some mornings, about once a month, I wake up feeling stoned and bizarre. At times, I can't feel my forehead. It's a feeling comparable to being hung over. To snap out of it, I have tried coffee, sugar and rest but the feeling remains. Do you have any advice to make it go away ?
Response from Dr. Conway
I addressed a question similar to this last week. There was a recent study of 37 individuals who were on Sustiva-based therapies, had undetectable viral loads and had side effects such as yours. They changed the Sustiva to Viramune, by adding Viramune at 200 mg/day for two weeks, then increasing the Viramune to 400 mg/day and only then stopping the Sustiva. There was 1/37 that had liver problems that immediately improved when the treatment was changed to Trizivir. The other 36 did fine, and the side effects disappeared in 24/36 cases.
If you change to Viramune, there is now information to suggest that it is highly likely to help, and it won't affect your viral load.
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