Side Effects & Neuropathy
Oct 31, 2003
I started taking Kaletra, Zerit & 3TC in July 2002. I started noticing problems in my feet about a month later and I was advised that I had peripheral neuropathy. The pain, burning and tightness got to be so bad, that in Jan. 2003 I asked to be removed from Zerit, and I was put on Combivir (I am still taking Kaletra with this).
Since then, I have tried two different types of accupuncture, and have spend hundreds of dollars on Gabapentin. I've also met with three neurologists, I've had nerve testing, and now I'm being sent for an MRI and more meetings with a neurologist.
Recently, while browsing thru material about side-effects of HIV meds, I noticed that 3TC and AZT (both of which are in Combivir) are also listed as causing neuropathy.
Why have none of my doctors told me that these meds can also contribute to the problem? I have had no relief from the treatments or Gabapentin; the pain can be excrutiating and I am never free from it (I never had it before taking the cocktail), and yet I'm continually going from one doctor to another trying to find relief.
We put our faith in our doctors -- what else do we know?
Any thoughts on why the doctors have not discussed this with me? And why can't they make the meds without all of these side-effects? I'm sure that I am not the only reader who is concerned with these issues.
Response from Dr. Conway
Neuropathy can be very troubling, as it seems to be in your case. Zerit and Videx are the two main drugs that have been associated with its development, while Epivir is not associated with it at all. For the other drugs, it may occur, although it is much less usual.
I will assume that the neurologists have not found another cause for your symptoms, and have also determined that it is, in fact, peripheral neuropathy. One issue that I would raise with you is whether a treatment interruption is a possibility to figure out if it really is the drug. If not, you can hang on to the Epivir, but talk to your doctor about other drugs that you could use. One example would be to add Viread and Sustiva to the Epivir, as this combination has been well studied in clinical trials, and has produced excellent results without any significant reports of neuropathy.
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