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Managing Side Effects of HIV TreatmentManaging Side Effects of HIV Treatment
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Oct 31, 2003

My husband is HIV+ for almost 20 years, now has Hep.C and has become anemic from the medication Copegus. He has been on Pegasys for almost 3 weeks. My question is what is causing the intense burning in his intestines and how soon will the exhaustion start to abate? He has been on Procrit for 2 weeks now due to the anemia. Should he see a GastroIntestinal MD as well as his Infectious Disease MD?

Response from Dr. Conway

You have not mentionned any HIV medications, so I will assume these are not in the picture. When taking pegylated interferon (Pegasys) and ribavirin (Copegus), the early part of the treatment is often the hardest, especially the day after the Pegasys dose. It will be important to monitor the hemoglobin, white blood cell count and tests of hepatic and pancreatic function over the first 6-8 weeks to see what is going on. In the meantime, all the symptoms he is having can be treated with appropriate supportive medication over the enxt month, unless the doctor determines something else is wrong. Some of the exhaustion may be due to interferon-associated depression, that may need to be addressed.

Many ID docs (such as I) feel comfortable dealing with all the aspects of HCV. It is up to you to discuss with your doc whether it may be of help to get a GI specialist involved.

Good luck over the next crucial month.

Drug combo. for slowing/halting lipoatrophy
Started treatment this year, CT shows splenomegaly

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